About

The Ray Truant Lab is located on the 4th Floor of McMaster Children’s Hospital, within the Department of Biochemistry and Biomedical Sciences.

Ray Truant completed his Bachelor’s degree at the University of Toronto, Victoria College, and continued on to his graduate studies in the Department of Medical Genetics in the lab of Jack F. Greenblatt at the C.H. Best Institute. For his graduate work, his studies focused on protein-protein interactions of the p53 tumor -suppressor protein and it’s mechanism of activation of transcription.

After receiving his doctorate in 1996, Ray studied as a post-doctoral Research Associate at the Howard Hughes Medical Research Institute at Duke University in the department of Genetics with Dr. Bryan R. Cullen. While at the HHMI, his research centered on protein-protein interactions of HIV-1 proteins and into mechanisms of protein transport to and from the nucleus using biochemical and cell biological techniques.

In 1999, Ray was appointed Assistant Professor in the Department of Biochemistry at McMaster University , where he started new projects on polyglutamine diseases, focusing on Huntington’s Disease. In 2001, Ray won the CIHR “New Scientist” award and his group is now supported by operating grants from Canada and the United States. In 2007, he was promoted to full Professor in Biochemistry and Biomedical Sciences. 

Professor Truant is Chair of the Scientific Advisory board of the Huntington Society of Canada since 2007.  He is a guest member of the CMND panel of the NIH, USA.  He is the External Scientific Advisor to HDBuzz website and on the Board of Reviewers at PloS Currents: HD. Dr. Truant is a recipient of the 2012 Queen Elizabeth II Diamond Jubilee Medal and the 2014 Michael Wright Community Leadership Award. Dr. Truant is a member of the CIHR College of Reviewers, and a past member of the CIHR CBMD and Cell Physiology panels, as well as reviewer for the Foundation and Project Competitions. 

The Truant lab is in an academic setting, but highly collaborative with pharmaceutical industry and biotech partners, as well as our clinical collaborators, Dr. Mark Guttman at the Centre for Movement Disorders in Toronto and Toronto Western Hospital and the University of Toronto, as well as Dr. Mark Tarnopolsky at McMaster’s Neuromuscular Disease Clinic.  Dr. Truant is on the Scientific Advisory Board of Mitokinin LLC, NY, a biotech firm dedicated to the development of small molecules drug therapy to restore the phosphorylation of mutant Huntingtin and thus treat Huntington’s disease.