Publications

Search all Ray Truant’s publications here

Greatest Hits:

Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex.

Maiuri T, Mocle AJ, Hung CL, Xia J, van Roon-Mom WM, Truant R.

Hum Mol Genet. 2017 Jan 15;26(2):395-406. doi: 10.1093/hmg/ddw395.

PMID: 28017939

DNA repair: A unifying mechanism in neurodegeneration.

Ross CA, Truant R.

Nature. 2017 Jan 5;541(7635):34-35. doi: 10.1038/nature21107. Epub 2016 Dec 21. No abstract available.

PMID: 28002410

DIXDC1 Phosphorylation and Control of Dendritic Morphology Are Impaired by Rare Genetic Variants.

Kwan V, Meka DP, White SH, Hung CL, Holzapfel NT, Walker S, Murtaza N, Unda BK, Schwanke B, Yuen RK, Habing K, Milsom C, Hope KJ, Truant R, Scherer SW, Calderon de Anda F, Singh KK.

Cell Rep. 2016 Nov 8;17(7):1892-1904. doi: 10.1016/j.celrep.2016.10.047.

PMID: 27829159

Huntingtin N17 domain is a reactive oxygen species sensor regulating huntingtin phosphorylation and localization.

DiGiovanni LF, Mocle AJ, Xia J, Truant R.

Hum Mol Genet. 2016 Sep 15;25(18):3937-3945. doi: 10.1093/hmg/ddw234. Epub 2016 Jul 27.

Nath S, Munsie LN, Truant R.

Hum Mol Genet. 2015 Jan 15;24(2):450-62. doi: 10.1093/hmg/ddu460. Epub 2014 Sep 8.

PMID: 25205111

Free PMC Article

Paperpile

Live cell imaging and biophotonic methods reveal two types of mutant huntingtin inclusions.

Caron NS, Hung CL, Atwal RS, Truant R.

Hum Mol Genet. 2014 May 1;23(9):2324-38. doi: 10.1093/hmg/ddt625. Epub 2013 Dec 11.

PMID: 24334607

Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin.

Caron NS, Desmond CR, Xia J, Truant R.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14610-5. doi: 10.1073/pnas.1301342110. Epub 2013 Jul 29.

PMID: 23898200

Free PMC Article

A multifunctional, multi-pathway intracellular localization signal in Huntingtin.

Desmond CR, Maiuri T, Truant R.

Commun Integr Biol. 2013 Mar 1;6(2):e23318. doi: 10.4161/cib.23318.

PMID: 23750301

Free PMC Article

Paperpile

The huntingtin N17 domain is a multifunctional CRM1 and Ran-dependent nuclear and cilial export signal.

Maiuri T, Woloshansky T, Xia J, Truant R.

Hum Mol Genet. 2013 Apr 1;22(7):1383-94. doi: 10.1093/hmg/dds554. Epub 2013 Jan 7.

The role of the cofilin-actin rod stress response in neurodegenerative diseases uncovers potential new drug targets.

Munsie LN, Truant R.

Bioarchitecture. 2012 Nov-Dec;2(6):204-8. doi: 10.4161/bioa.22549.

PMID: 23267414

Free PMC Article

Paperpile

Identification of a karyopherin β1/β2 proline-tyrosine nuclear localization signal in huntingtin protein.

Desmond CR, Atwal RS, Xia J, Truant R.

J Biol Chem. 2012 Nov 16;287(47):39626-33. doi: 10.1074/jbc.M112.412379. Epub 2012 Sep 25.

PMID:23012356

Free PMC Article

Using FLIM-FRET to measure conformational changes of transglutaminase type 2 in live cells.

Caron NS, Munsie LN, Keillor JW, Truant R.

PLoS One. 2012;7(8):e44159. doi: 10.1371/journal.pone.0044159. Epub 2012 Aug 31.

PMID: 22952912

Free PMC Article

Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.

Di Pardo A, Maglione V, Alpaugh M, Horkey M, Atwal RS, Sassone J, Ciammola A, Steffan JS, Fouad K, Truant R, Sipione S.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3528-33. doi: 10.1073/pnas.1114502109. Epub 2012 Feb 13.

PMID: 22331905

Free PMC Article

Kinase inhibitors modulate huntingtin cell localization and toxicity.

Atwal RS, Desmond CR, Caron N, Maiuri T, Xia J, Sipione S, Truant R.

Nat Chem Biol. 2011 May 29;7(7):453-60. doi: 10.1038/nchembio.582.

PMID: 21623356

Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease.

Munsie L, Caron N, Atwal RS, Marsden I, Wild EJ, Bamburg JR, Tabrizi SJ, Truant R.

Hum Mol Genet. 2011 May 15;20(10):1937-51. doi: 10.1093/hmg/ddr075. Epub 2011 Feb 25.

PMID: 21355047

Free PMC Article

Lifeact cannot visualize some forms of stress-induced twisted F-actin.

Munsie LN, Caron N, Desmond CR, Truant R.

Nat Methods. 2009 May;6(5):317. doi: 10.1038/nmeth0509-317. No abstract available.

PMID: 19404250

Huntington’s disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases.

Truant R, Atwal RS, Desmond C, Munsie L, Tran T.

FEBS J. 2008 Sep;275(17):4252-62. doi: 10.1111/j.1742-4658.2008.06561.x. Epub 2008 Jul 15. Review.

PMID: 18637947

Free Article

Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity.

Atwal RS, Xia J, Pinchev D, Taylor J, Epand RM, Truant R.

Hum Mol Genet. 2007 Nov 1;16(21):2600-15. Epub 2007 Aug 18.